There are several "failsafes" that are in play here and you have risk at each one. Having put 5,000 miles on my V8 I have noticed a few things.
1. The tire: this is the first failsafe. Yes more power will make it spin but there are some measures you can take to get more grip - stickier tire, wider tire, softer rear spring, softer rebound setting, etc. I have several of theservice in place to get better grip. Don't assume that since you can spin the tire in 2nd, 3rd, and 4th with 260hp that 500hp is worthless.
2. Belt slippage. This one is difficult to overcome because you don't want to over-tighten the belt. I have jammed on the gas at 50 mph and slipped the belt due to power. Sounds like the rear end is exploding. Better than the rear end actually exploding.
3. Angle drive. The main weakness of the angle drive is the casing. The internals/gears aren't half bad. Hopefully there will be a fix for this in the near future There could be better fluid dispersion but that's another topic.
4. Drive shaft. I replaced mine and I suggest anyone considering high power levels do the same. They aren't terribly expensive or hard to get. A great piece of mind considering if the end disinigrates it is right next to you and your passenger's asses.
5. Tranny: clutch and transmission will need to be upgraded significantly. My 5sp showed signs of wear after just 4,000 miles with the turbo and that was at 260-270hp. Ram 350-500 through it and look out. I believe DDM has a great clutch upgrade and you should just do factor the $$$ into the turbo upgrade.